A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Rai, Yogesh Kumar
- A Study of Protective effect of Ginger (Zingiber Officinale) in Normal and Carbon-Tetrachloride Induced Hepatotoxic Rats in Western U.P. India
Authors
1 Department of Medicine, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
2 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
3 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
Source
Indian Journal of Forensic Medicine & Toxicology, Vol 7, No 2 (2013), Pagination: 64-67Abstract
The current study has been conducted to investigate the affect of ginger on hepatic antioxidant enzymes system in carbon tetrachloride induced hepatotoxic rats. The first set of animals received only ginger-supplemented diet while the another set were treated with CCl4 before maintaining them on ginger-based diets.Consumption of the experimental diets by the normal rats produced significant elevation (p<0.05) in the activities of the hepatic aspartate aminotransferase and alanine aminotransferase as well as the concentration of protein and albumin. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters . However, the significantly reduced (p<0.05) marker enzymes such as AST, ALT, due to CCl4 treatment were restored towards normalization on consumption of ginger diet. The biochemical parameters like total protein and albumin were also restored towards normal levels. The findings indicate that the ginger is an efficient hepatoprotective and antioxidant agent against CCl4-induced liver toxicity.Keywords
Aminotransferases, Carbon tetrachloride (CCl4), De novo synthesis Hepatotoxicity, SpicesReferences
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- A Study of effect of Phenytoin on Liver Enzymes in Epileptic Patients in Western Uttar Pradesh
Authors
1 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
2 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
Source
International Journal of Contemporary Medicine, Vol 1, No 2 (2013), Pagination: 11-14Abstract
Aim & Objective: In this study, we investigated the effects of phenytoin on hepatic enzyme levels in epileptic patients.
Method: In this prospective clinical study, we measured the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT) on 120 epiteptic patients. consecutive admissions to our epilepsy unit.
Result: Serum gamma glutamyl transferase (gammaGT), AST, ALT activities have been estimated in 120 epileptic patients taking Phenytoin as anticonvulsant drugs. Serum AST, ALT & GGT levels were increased.
Conclusion: We found most of our patients on Phenytoin had an elevated serum concentration of GGT, which is consistent with previous reports. AST and ALT were also elevated in these patients and therefore suggested the increased GGT was due to enzyme induction. Elevation of GGT needs to be considered differently in light of the use of new antiepileptic medications.
Keywords
Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma-glutamyl Transpeptidase (GGT), Metabolic Abnormalities, Phenytoin (PHT).References
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- Valproate-induced Subclinical Hypothyroidism
Authors
1 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., IN
2 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., IN
3 Department of Obstetrics & Gynecology, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., IN
Source
Indian Journal of Forensic Medicine & Toxicology, Vol 5, No 1 (2011), Pagination: 110-112Abstract
Introduction:
Sodium valproate (VPA) is widely used for the treatment of partial and generalized epilepsy in childhood and adolescence. The results of the studies that have evaluated the effect of VPA monotherapy on thyroid function in epileptic patients are controversial.
Objective:
Studies on the effects of sodium valproate on thyroid hormone balance in patients with epilepsy are conflicting. The aim of this study was to prospectively evaluate the changes in thyroid profile in epilepsy treated with valproate monotherapy.
Methods:
Serum level of triiodothyronine (T3), thyroxin (T4) and thyroid stimulating hormone (TSH) were determined in 40 epileptic patients of valproate monotherapy by EIA method.
Results:
Epileptic patients had slightly decreased triiodothyronine (T3) and thyroxin (T4), whereas TSH level was significantly increased on valproate monotherapy.
Conclusion:
The results showed that valproate may induce subclinical hypothyroidism. This suggests a need for careful monitoring of serum TSH level in epileptic patients receiving valproate drug.
Keywords
Antiepileptic Drugs (AEDS), Epilepsy, Thyroid Hormones, Endocrinological System, Subclinical Hypothyroidism, Valproate (VPA).References
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- Chronic Renal Failure and Hypothyroidism
Authors
1 Department of Pharmacology, Saraswathi Institute of Medical Sciencies, Hapur, Ghaziabad, U.P., IN
2 Department of Biochemistry, Saraswathi Institute of Medical Sciencies, Hapur, Ghaziabad, U.P., IN
3 Department of Medicine, Saraswathi Institute of Medical Sciencies, Hapur, Ghaziabad, U.P., IN
Source
Indian Journal of Public Health Research & Development, Vol 3, No 1 (2012), Pagination: 174-177Abstract
This study was undertaken to test the thyroid function with chronic renal failure. Forty patients of CRF and forty healthy who served as control were studied for their thyroid function status. The study observed low total T3 and total T4 values in clinically euthyroid CRF patients. However, finding of normal free T4 values (which is metabolically active fraction) and TSH would indicate functional euthyroid status. It can be presumed that free T4 values would fall if these patients develop hypothyroidism, and TSH values would rise simultaneously. Thus free T4 and TSH level combined can be used for diagnosis of hypothyroidism in presence of chronic renal failure. This study found that the plasma concentrations of thyroid hormones in patients with chronic renal failure both free T3 1.38±0.31 pmol/L and total T3 serum concentrations1.06±0.23 nmol/L were reduced as compare to control respectively. Similarly both serum freeT4 06.27±1.09 pmol/L and total T4 56.17±0.8.96 nmol/L were also reduced in chronic renal failure patients .There was slightly increase in serum TSH 6.21±0.73 mlU/L as compared to control 3.43±0.44 mlU/L. Thus it is suggested that thyroid hormones should be evaluated in chronic renal failure patients and thyroid hormone therapy should be given in these patients to maintain thyroid hormone level.Keywords
Chronic Renal Failure (CRF), Creatinine Clearance, Goiter, Hypothyroidism, Thyroid Hormones (TH)References
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